synthesis, characterization and anti-inflammatory activity of some 1, 3,4 -oxadiazole derivatives

نویسندگان

arvind kumar singh kamla nehru institute of management and technology, faculty of pharmacy, sultanpur up, india.

m. lohani integral university luck now, uttarpradesh india.

r. parthsarthy kamla nehru institute of management and technology, faculty of pharmacy, sultanpur up, india.

چکیده

a series of five-membered heterocyclic rings were synthesized by the reaction between benzoyl chloride and various chlolro-nitro-benzoyl chlorides and semi carbazide to form (c1-c7) compounds and was tested for their anti-inflammatory activity determined by rat-paw-oedema method. all the synthesis compounds have been characterized by 1hnmr, ir and mass spectral data. the compounds were purified by column chromatography. all synthesized derivatives were determined by the carrageenan-induced rat-paw-oedema model for anti-inflammatory activity. the entire compound gives good response for the anti-inflammatory activity: [3-chloro-n-[5-(3-chloro-phenyl)-[1,3,4] oxadiazole-2yl] benzamide (c4), and [4-nitro-n-[5-(4-nitro-phenyl)-[1,3,4] oxadiazole-2yl] benzamide (c7). for this activity, indometacin was used as a standard drug and compared to new synthesized drugs. some new synthesized drugs have shown better activities for the anti-inflammation.

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Synthesis, Characterization and Anti-Inflammatory Activity of Some 1, 3,4 -Oxadiazole Derivatives

A series of five-membered heterocyclic rings were synthesized by the reaction between benzoyl chloride and various chlolro-nitro-benzoyl chlorides and semi carbazide to form (C1-C7) compounds and was tested for their anti-inflammatory activity determined by rat-paw-oedema method. All the synthesis compounds have been characterized by 1HNMR, IR and Mass spectral data. The compounds were purified...

متن کامل

Synthesis, Characterization and Anti-Inflammatory Activity of Some 1, 3,4 -Oxadiazole Derivatives

A series of five-membered heterocyclic rings were synthesized by the reaction between benzoyl chloride and various chlolro-nitro-benzoyl chlorides and semi carbazide to form (C1-C7) compounds and was tested for their anti-inflammatory activity determined by rat-paw-oedema method. All the synthesis compounds have been characterized by 1HNMR, IR and Mass spectral data. The compounds were purified...

متن کامل

Synthesis, Characterization and Anti-Inflammatory Activity of Some 1, 3,4 -Oxadiazole Derivatives

A series of five-membered heterocyclic rings were synthesized by the reaction between benzoyl chloride and various chlolro-nitro-benzoyl chlorides and semi carbazide to form (C1- C7) compounds and was tested for their anti-inflammatory activity determined by rat-paw-oedema method. All the synthesis compounds have been characterized by (1)HNMR, IR and Mass spectral data. The compounds were purif...

متن کامل

synthesis and characterization of some macrocyclic schiff bases

ماکروسیکلهای شیف باز از اهمیت زیادی در شیمی آلی و دارویی برخوردار می باشند. این ماکروسیکلها با دارابودن گروه های مناسب در مکانهای مناسب می توانند فلزاتی مثل مس، نیکل و ... را در حفره های خود به دام انداخته، کمپلکسهای پایدار تولید نمایند. در این پایان نامه ابتدا یک دی آلدئید آروماتیک از گلیسیرین تهیه می شود و در مرحله بعدی واکنش با دی آمینهای آروماتیک و یا آلیفاتیک در رقتهای بسیار زیاد منجر به ت...

15 صفحه اول

Synthesis and antimicrobial activity of some novel oxadiazole derivatives.

A series of 5-(3'-oxo-6'-(substituted aryl)-2',3',4',5'-tetrahydropyridazin-2'-ylmethyl )-2-substituted 1,3,4-oxadiazole has been synthesized. Appropriate aromatic hydrocarbon reacts with succinic anhydride in the presence of AICl3 to yield beta-aroyl propionic acid (1a). The corresponding acid is cyclized with hydrazine hydrate to give 6-(substituted aryl)-2,3,4,5-tetrahydro-3-pyridazinone (1b...

متن کامل

Design and Microwave-assisted Synthesis of 1,3,4-Oxadiazole Derivatives for Analgesic and Anti-inflammatory Activity

1,3,4-Oxadizoles form a biologically important group of compounds having activities like analgesic, anti-inflammatory, bactericidal, antifungal, anticonvulsant, psychotropic, plant growth regulating and mono amino oxidase inhibition. This research has focused on the incorporation of the oxadiazole moiety into isoniazid because of their versatile biological action, to get 2-aryl-5-(4-pyridyl)-1,...

متن کامل

منابع من

با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید


عنوان ژورنال:
iranian journal of pharmaceutical research

جلد ۱۲، شماره ۲، صفحات ۳۱۹-۳۲۳

کلمات کلیدی
[ 1 , 3 , 4 , ' o x a d i a z o l e s ' , ' a n t i ' , ' i n f l a m m a t o r y ' , ' s y n t h e s i s ' , ' h e t e r o c y c l i c ' ]

میزبانی شده توسط پلتفرم ابری doprax.com

copyright © 2015-2023